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足底測(cè)試儀是用以測(cè)量嚙齒類(lèi)動(dòng)物對(duì)紅外熱刺激的反應(yīng)。聚焦紅外光源于動(dòng)物足底，按下開(kāi)關(guān)，等待動(dòng)物縮回受測(cè)爪，儀器自動(dòng)記錄紅外光強(qiáng)度和持續(xù)時(shí)間。實(shí)驗(yàn)數(shù)據(jù)會(huì)顯示在液晶屏上，也可導(dǎo)入閃存中，或在通過(guò)USB數(shù)據(jù)線導(dǎo)入至電腦中。

命令：	軟鍵		數(shù)據(jù)轉(zhuǎn)移：	配備的閃存
數(shù)據(jù)讀?。?/strong>	液晶屏顯示		電源：	universal mains 85-264 VAC, 50-60Hz
打?。?/strong>	熱敏打印機(jī)（需另外購(gòu)買(mǎi)）		工作溫度	15°- 30°C
開(kāi)始：	紅外光源開(kāi)關(guān)		聲級(jí)：	< 70 dB
紅外光強(qiáng)度：	01-99級(jí)間可調(diào)		校準(zhǔn)：	紅外輻射計(jì)
反應(yīng)時(shí)間：	顯示在液晶屏上；分辨率為0.1s		連接電腦：	DELTA 9-pin連接器.參看說(shuō)明書(shū)3.5
紅外燈泡： 規(guī)格： 動(dòng)物罩子： 凈重： 毛重： 包裝規(guī)格：	Halogen "Bellaphot", Mod. 64607 OSRAM, 8V-50W 85 x 40 x 35 cm 3個(gè)，每個(gè)20x20x14(h)cm 13.0kg 約27.5kg 109 x 53 x 55 cm

足底測(cè)試儀刺激強(qiáng)度值（紅外熱輻射值）對(duì)照表（單位：mW/cm2）

方法

- D.C. Yeomans & H.K. Proudfit: “Characterization of the Foot Withdrawal Response to Noxious Radiant Heat in the Rat” Pain 59: 85-97, 1994.

- K.M. Hargreaves, R. Dubner, F. Brown, C. Flores and J. Joris: "A New and Sensitive Method for Measuring Thermal Nociception in Cutaneous Hyperalgesia." Pain 32: 77-88, 1988.

提及UB產(chǎn)品的文獻(xiàn)

- V. Vacca et alia: “Botulinum Toxin A Increases Analgesic Effects of Morphine, Counters Development of Morphine Tolerance and Modulates Glia Activation and μ Opioid Receptor Expression in Neuropathic Mice” Brain, Behav and Immunity 32: 40-50, 2013

- A. Finley et alia: “Sphingosine 1-Phosphate Mediates Hyperalgesia via a Neutrophil-Dependent Mechanism” PLoS ONE 8(1): e55255, 2013

- J. Donnerer et alia: “The Pain Pathway in the Rat following Noxious Thermal Stimulation: Effect of Morphine on pERK1/2 and TRPV1 at the Dorsal Horn Level, and on Hyperalgesia” Pharmacology 92: 32-38, 2013

- M. Arai et alia: “The miRNA and mRNA Changes in Rat Hippocampi after Chronic Constriction Injury”P(pán)ain Medicine 14 (5): 720-729, 2013

- P.J. Austin et alia: “G. Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats” JoVE 61, e3393, doi:10.3791/3393, 2012 http://www.jove.com/video/3393/chronic-constriction-sciatic-nerve-pain-hypersensitivity-testing

- H.N. Kim et alia: “Electroacupuncture Inhibits Phosphorylation of Spinal Phosphatidylinositol 3-kinase/Akt in a Carrageenan-induced Inflammatory Rat Model” Brain Res. Bulletin 87 (2-3): 199-204,2012

- D. Piomelli et alia: ”Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism” Nature NSC, 2010

- C.B. Vaegter et alia: ”Sortilin Associates with Trk Receptors to Enhance Anterograde Transport and Neurotrophin Signaling” Nature NSC, 2010

- O. Ortiz et alia: “Associative Learning and CA3–CA1 Synaptic Plasticity Are Impaired in D1R Null,Drd1a-/- Mice and in Hippocampal siRNA Silenced Drd1a Mice” J. Neuroscience 30 (37): 12288-12300,2010

- M. Rosemann et alia: “Microphthalmia, Parkinsonism, and Enhanced Nociception in Pitx3416insGMice” Mamm Genome 21: 12-27, 2010

- Mark J. Field et alia: “Detection of Static and Dynamic Components of Mechanical Allodynia in Rat Models of Neuropathic Pain: Are They Signalled by Distinct Primary Sensory Neurones?” Pain 83: 303-311, 1999

- Fred Lembeck: “Epibatine: High Potency and Broad Spectrum Activity on Neuronal and Neuromuscular Nicotinic Acetylcholine Receptors” Naunyn-Schmiedeberg’s Arch. Pharmacol. 359:378-385, 1999

- Hartmut Buerkle et alia: “Experimental Arthritis in the Rat Does Not Alter the Analgesic Potency of Intrathecal or Intraarticular Morphine” Anesth. Analg. 89: 403-408, 1999.

- F.G. Garrett, P.L. Durham et alia: “Validation of a Novel Rat-Holding Device for studying heat- and mechanical-Evoked Trigemi-nal Nocifensive Behavioral Responses” J. Orofacial Pain, 26 (4): 336- 344, 2012

- F.G. Garrett, P.L. Durham et alia: “Development of a novel device for measuring withdrawal latency by thermal stimulation in rodent facial pain models using the Hargreaves Plantar Apparatus” Poster presented at SFN 201