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轉(zhuǎn)棒實驗是運動協(xié)調(diào)方面藥物篩選的重要方法。根據(jù) N.W Dunham 和 T.S Miya 1957年的論文。在1960年，Ugo Basile設(shè)計了第一個RotaRod轉(zhuǎn)棒儀。

數(shù)據(jù)讀?。?/strong>	液晶顯示	數(shù)據(jù)采集：	52050-07軟件
轉(zhuǎn)棒開始：	START (藍色)鍵	電源：	universal input 85-264 VAC, 50-60Hz,最大40 W
轉(zhuǎn)棒停止：	RESET/STOP(紅色)鍵	工作溫度：	10°- 40°C
設(shè)置速度：	功能鍵	聲級：	< 60 dB
速度重置：	RESET/STOP (紅色)鍵	打?。?/strong>	7145微型熱敏打印機（需購置）
轉(zhuǎn)子：	直徑3cm轉(zhuǎn)鼓

物理尺寸
凈重：	11.0 Kg
尺寸：	46 (w) x 28 (d) x 33 (h) cm
毛重：	Kg 16.0 (approx.)
包裝尺寸： 轉(zhuǎn)子： 走道寬度： 下落高度：	66 x 50 x63 cm 直徑3cm 5.7cm 16cm

特征	優(yōu)點
轉(zhuǎn)速可調(diào)5-80RPM，每次1RPM	予以小鼠舒適的活動環(huán)境
勻速，加速，多次加速模式（新）	可用于研究運動學(xué)習(xí)機運動功能
可使用USB閃存盤	無需連接電腦即可儲存數(shù)據(jù)
新版軟件	新款觸摸屏能夠設(shè)置實驗參數(shù)、管理實驗數(shù)據(jù)。

方法文獻

§ N.W. Dunham & T.S. Miya: “A Note on a Sinple Apparatus for Detecting Neurological Deficit in Rats & Mice“ J. Am. Pharmaceut. Assoc., Scientific Edit., XLVI: No. 3, 1957

§ B.J. Jones & D.J. Roberts: “The Quantitative Measurement of Motor Inco-ordination in Naive Mice Using an Accelerating Rotarod“ J. Pharm. Pharmac.: 20: 302-304, 1968

使用轉(zhuǎn)棒儀技術(shù)的相關(guān)文獻：

§ B.J. Turner et alia: “Overexpression of Survival Motor Neuron Improves Neuromuscular Function and Motor Neuron Survival in Mutant SOD1 Mice” Neurobiol. Of Aging 35 (4): 906-915,2014

§ M. Milanese et alia: “Knocking Down Metabotropic Glutamate Receptor 1 Improves Survival And Disease Progression in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis” Neurobiology of Disease 64: 48-59, 2014

§ J.E. Lorenz: “Oxidant-Induced Activation of cGMP-Dependent Protein Kinase Iα Mediates Neuropathic Pain After Peripheral Nerve Injury” Antioxidants & Redox Signaling Jan. 2014

§ J.N. Justice et alia: “Battery of Behavioral Tests in Mice that Models Age-Associated Changes in Human Motor Function” Age Oct 2013

§ A.S. Hamlin et alia: “Lesions of the Basal Forebrain Cholinergic System in Mice Disrupt Idiothetic Navigation” PLoS ONE 8(1): e53472, 2013

§ T. Rantam?ki et alia: “The Impact of Bdnf Gene Deficiency to the Memory Impairment and Brain Pathology of APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease” PLoS ONE 8(7): e68722, 2013

§ T. Murakami et alia: “Vascular Endothelial Growth Factor Electro-Gene Therapy Improves Functional Outcome in a Mouse Model of ALS” Immunology, Endocrine & Metabolic Agents: 13 (2): 107-111, 2013

§ R. Günther et alia: “Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)” JoVE J. Vis. Exp. (61), e3936, doi:10.3791/3936, 2012http://www.jove.com/video/3936/clinical-testing-spinal-cord-removal-mouse-model-for-amyotrophic

§ A.J. Grottick et alia: “Studies to investigate the role of 5-HT 2C Receptors on Cocaine- and Food-Maintained Behavior”: J. Pharmacol. Exper. Therap., 2000

§ L.T. Huang et alia: “Pentylenetetrazol-Induced Recurrent Seizures in Rat Pups: Time Course on Spatial Learning and Long…”: Epilepsia, 2002

§ E. Candelario-Jalil et alia: “Wide Therapeutic Time Window for Nimesulide Neuroprotection in a Model of Transient Focal Cerebral Ischemia in the Rat”: Brain Research: 177: 98-108, 2004

§ C.D. Heldermon et alia: “CliTherapeutic Efficacy of Bone Marrow Transplant, Intracranial AAV-mediated Gene Therapy, or Both in the Mouse Model of MPS IIIB” Molecular Therapy 15(5): 873-880, 2010  (rocking)